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Rofecoxib - Wikipedia
Rofecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug . It was marketed by Merck & Co. to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea.
Vioxx: Side Effects, Dosage & Uses -
Vioxx should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart. Do not take Vioxx without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Vioxx passes into breast milk.
Vioxx | Treatment for Arthritis & Recall for Patient Deaths
When Vioxx (rofecoxib) received its FDA approval in 1999, it was the second drug of its kind in a relatively new class of painkiller drugs called selective nonsteroidal anti-inflammatory drugs (or NSAIDs).
What have we learnt from Vioxx? - PubMed Central (PMC)
Rofecoxib (Vioxx) was introduced by Merck in 1999 as an effective, safer alternative to non-steroidal anti-inflammatory drugs for the treatment of pain associated with osteoarthritis. It was subsequently found to increase the risk of cardiovascular disease and withdrawn from the worldwide market.
Vioxx: This Pharmaceutical Drug Killed Over 60,000 People
Vioxx was a so-called blockbuster drug—a designation given to extremely popular drugs that generate a minimum of $1 billion in annual sales. Vioxx was marketed in more than 80 countries, and pulled in $2.5 billion in worldwide sales in 2003 alone (the year before it was pulled from the market due to its heart risks).
Vioxx - definition of Vioxx by The Free Dictionary
Vioxx synonyms, Vioxx pronunciation, Vioxx translation, English dictionary definition of Vioxx. Noun 1. Vioxx - a Cox-2 inhibitor that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004 ...
Vioxx (Rofecoxib): Uses, Dosage, Side Effects ...
VIOXX has demonstrated significant reduction of joint tenderness/pain and joint swelling compared to placebo. VIOXX was evaluated for the treatment of the signs and symptoms of RA in two 12-week placebo- and active-controlled clinical trials that enrolled a total of approximately 2,000 patients.
Vioxx: The Downfall of a Drug : NPR
Vioxx: The Downfall of a Drug Merck removed one of the world's best-selling painkillers from the market in 2004 after a study showed Vioxx caused an increased risk of serious cardiovascular events, such as stroke and heart attack.
Vioxx | definition of Vioxx by Medical dictionary
Pfizer halted advertising of Celebrex soon after Vioxx, a similar arthritis drug manufactured by Merck & Co., was withdrawn from the market in 2004.
Vioxx took deadly toll: study - The Globe and Mail
Vioxx, the blockbuster arthritis and pain medication pulled off the market last September, could have killed more than 40,000 people in the United States, according to an FDA scientist who has said his employer silenced his earlier warnings about the drug's safety.
Merck Manipulated the Science about the Drug Vioxx | Union ...
In fact, Vioxx has since been found to significantly increase cardiovascular risk, leading Merck to withdraw the product from the market in 2004. Merck’s manipulation of the science around Vioxx also included a pattern of ghostwriting of scientific articles.
Vioxx (Rofecoxib) | Therapeutic Goods Administration (TGA)
The company has decided to recall VIOXX based on new information from a recent clinical study which showed that there was an increased risk of cardiovascular events such as heart attack and stroke beginning after 18 months of treatment, in the patients taking Vioxx at a dose of 25 mg once daily.
Bringing Vioxx back to market | The BMJ
Regulatory and transparency safeguards are essential to protect patients In 1999, the US Food and Drug Administration (FDA) approved rofecoxib (Vioxx) for the treatment of acute pain and the pain associated with osteoarthritis. Its manufacturer, Merck, marketed the drug as an effective, safer alternative to non-steroidal anti-inflammatory drugs ...
Merck & Co. - Wikipedia
Merck adjusted the labeling of Vioxx to reflect possible cardiovascular risks in 2002. [citation needed] On September 23, 2004, Merck received information about results from a clinical trial it was conducting that included findings of increased risk of heart attacks among Vioxx users who had been using the medication for over eighteen months. ...
Side Effects of Vioxx (Rofecoxib), Warnings, Uses
Our Vioxx (rofecoxib) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Timeline: The Rise and Fall of Vioxx : NPR
Timeline: The Rise and Fall of Vioxx Five years after Vioxx's launch in 1999, Merck withdrew the drug from the market. By that time, Merck had sold billions of dollars worth of the painkiller worldwide.

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